Thrombophilia in the pathogenesis of fetal growth retardation

Familial thrombophilia and the occurrence of fetal growth restriction.

BACKGROUND AND OBJECTIVES To evaluate the association between unexplained or gestational-hypertension-associated fetal growth restriction (FGR) and factor V Leiden, prothrombin A20210 mutations, and methylenetetrahydrofolate reductase (MTHFR) TT 677 genotype. DESIGN AND METHODS Sixty-one women with a previous history of FGR and 93 parous women with uneventful pregnancies from the same ethnic ...

One Case of Improving Weight Gain in Asymmetric Fetal Growth Retardation with a Diet based on Iranian Traditional Medicine

Background: Intrauterine growth retardation (IUGR), that is, an estimated fetal weight less than ten percent of the standard weight for gestational age, is one of the important challenges in modern obstetrics, the management and treatment of which is cause-dependent. Given the lack of an accepted treatment for these patients, this study aimed to introduce a treatment commonly u...

12 Fetal Thrombophilia

Unexplained fetal growth retardation: what is the cause?

Recent epidemiological studies suggest a link between reduced fetal growth and the subsequent development of hypertension and diabetes in adult life.1-5 An understanding of the aetiology of fetal growth retardation is therefore of increased importance. Fetal adaptations to an adverse uterine environment, of which low birth weight is the most obvious marker, may 'programme' an individual in such...

Assessment of intra-uterine growth retardation by fetal magnetocardiography

Fetal magnetocardiography allows the noninvasive registration of the prenatal cardiac electrophysiological signal. The good signal-to-noise characteristics of most biomagnetometers combined with adequate signal processing techniques generally permit the identification of the fetal deand repolarization onsets and offsets to an accuracy of 1 ms. The P wave, QRS complex and sometimes the T wave ca...